A few years ago I took a gamble at the game store and picked up a funny little card game called Bang! The basic premise is that you and your opponents are all Old West gunslingers stuck in a spaghetti western (all the cards are printed in Italian).
Everyone randomly draws different characters with different advantages. Then everyone draws a job which determines your goal for the game. The wide variety of cards lets you shoot at your neighbors around the table, heal yourself by drinking a beer, or sending the Indians after everyone, among other interesting choices.
I highly recommend the game as a fun part of holiday family get-togethers. But watch out.
Bang!
http://ovrnite.com/board-games/bang/2007/11/29/
http://ovrnite.com/