I've always wanted to run a game where Mister Slayer finds out that he exists in an RPG, that there are other RPG's, and goes off to conquer them to take what he can for the WoP. The players would be part of a ragtag resistance movement, based out of the Floating Vagabond or somewhere similar, chasing Mister Slayer and his sinister agents through the multiverse to stop this. It wouldn't be quite as grim as SLA, it's basically an excuse for a giant crossover, but it could be a good time.
Cross-over could be fun. That'd be a multiverse traversing leap across the 4th wall! I think the term would be "gonzo". Slayer siding with the Yozi from Exalted with their Sith minions. But what's this? The forces of good seek to rally behind Elminster and the Aeon Trinity with support from the Camarilla!