Certainly in terms of economics. Entirely different. Much deeper and more involved.
Oh, Leviathans? Yeah, warfare, too.
Exploration's largely the same, though. Unless... Were there still the three different FTL alternatives at that time? Because there's only the hyperlane version by default (okay, with some rare special techs that allow some degree of "offroad" travel and long jumps).
So, overall? Yeah, it's a pretty different game now.