Former ACME QA Tester.
As mention Takeshi Kovacs novels (Altered Carbon, Broken Angels, Woken Furies) are cyberpunk books set in furture where mind uploads (and things that go with them like resevling, forking, or putting minds in reality simulations) are common place.Higher-end transhumanist tech probably doesn't mesh well with cyberpunk ideas. Because when minds are readily read-writable data, the oppressive all-controlling organizations are simply going to reformat the population to their taste and then any surviving people retaining the capacity to be cyberpunk protagonists will be completely expelled from the society rather than left on the fringes for future exploitation. And once there's no dissent in the hive, the punk is gone.
The thing is society still need Cyberpunk PC-like character to do it's dirty deeds. Kovack himself is an ex-Envoy, an elite spec-ops military formation, created to preferom opperation raging from assasination to political manipulations, in fairly PC like manner. The idea is the Envoy are trained and condition to be the operative there can be, and one or small group is send to deal with problems on planetary scale.