My first inclination would be to run something small scale and personal about people who happen to get caught in the crossfire when any of the numerous ongoing political conflicts boil over. PCs being PCs they'll end up in deep somehow or other and the rest should flow from there. The one downside is that this is basically what the show did (I can't speak to the books), which could make it appear derivative.
My plan is to have the PCs be on Eros when "da felota fo erluf" and have them grab one of the small ships docked on Eros when the people headed for that ship get cut off by Holden, Miller, etc. From there, I think they can figure something out.